Preparation and characterization of bio-adhesive Metformin Hydrochloride tablets (model drug)
Abstract
The aim of this study was to prepare bio-adhesive tablets containing a model drug
(eq. Metformin Hydrochloride) and to study the effect of bio-adhesive excipients on the properties of the prepared tablets. Matrix tablets were prepared by compression after wet granulation method using carbopol 940p, sodium alginate and croscarmellose sodium as bio-adhesive polymers. The properties of granules as flowbility and residual moisture and the properties of tablets (in terms of hardness, friability, weight uniformity, content uniformity, swelling index, ex vivo bio-adhesive time and strength and In vitro drug release) were evaluated. The results showed that the combination between carbopol 940p and sodium alginate (F3) achieved the longest bioadhesion time (˃9hrs) and longest drug release (11hrs). Drug release kinetics showed that drug release mechanism was to be zero order in most formulations. The results also showed that an increase of carbopol 940p amount led to an increase in bio-adhesion strength, bio-adhesion time and swelling index.
Downloads
Published
Issue
Section
License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
The authors retain the copyright and grant the right to publish in the magazine for the first time with the transfer of the commercial right to Tishreen University Journal for Research and Scientific Studies - Health Sciences Series
Under a CC BY- NC-SA 04 license that allows others to share the work with of the work's authorship and initial publication in this journal. Authors can use a copy of their articles in their scientific activity, and on their scientific websites, provided that the place of publication is indicted in Tishreen University Journal for Research and Scientific Studies - Health Sciences Series . The Readers have the right to send, print and subscribe to the initial version of the article, and the title of Tishreen University Journal for Research and Scientific Studies - Health Sciences Series Publisher
journal uses a CC BY-NC-SA license which mean
You are free to:
- Share — copy and redistribute the material in any medium or format
- Adapt — remix, transform, and build upon the material
- The licensor cannot revoke these freedoms as long as you follow the license terms.
- Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- NonCommercial — You may not use the material for commercial purposes.
- ShareAlike — If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
