EFFECT OF AMOUNT OF HYDROPHOBIC LUBRICANT AND MIXING TIME ON PARACETAMOL TABLETS PROPERTIES
Abstract
Magnesium stearate (Mg-St) is a widely used lubricant in solid drug formulations. In this research, we examined the effect of the lubricant magnesium stearate at various concentrations, mixing times, and mixers on granule flowability and paracetamol tablet properties (hardness, friability, disintegration time, and dissolution rate). It was found that increasing the mixing time of MgSt improved granule flow and reduced hardness statistically significantly, while increasing the MgSt concentration and the type of mixer did not have a statistically significant effect on the flowability and hardness. On the other hand, the disintegration time increases and the dissolution rate decreases statistically with increasing MgSt concentration and mixing time.
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