The role of immunohistochemistry P53 ,Ki-67, Bcl-2 In colorectal carcinoma prognosis
Abstract
BACKGROUND: The incidence of colorectal cancer is rising over time, as it is the most common cause of cancer deaths after lung cancer. And the survival rate of 5 years is weak.
METHODS: We investigated the following IHC status p53, Ki-67, Bcl-2 in 80 colorectal cancer cases distributed over the years 2017-2019 from Tishreen University Hospital reviewers. The relationship of IHC prevalence to prognostic factors: age, tumor size, stage, grade, histological pattern, and presence of distant or lymph metastases. The cross-sectional statistical study was completed by using the SPSS program.
RESULTS: the tumor size in half of the cases >5 cm, 60% of the tumors were on the left side, metastases appeared in the lymph nodes in 53.75% of the cases, 10% of the patients suffered from distant metastases upon diagnosis, the results of IHC staining are as follows p53 (positive 48.75%), Bcl-2 (positive 55%) and severe positive Ki-67, 26.25%.
CONCLUSION: The presence of strong positivity Ki-67, P53 indicates an increase in
aggressive biological behavior, which calls for effective aggressive treatment with these
tumors to improve the prognosis.Bcl2 high expression correlated with good prognosis in CRC
Downloads
Published
Issue
Section
License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
The authors retain the copyright and grant the right to publish in the magazine for the first time with the transfer of the commercial right to Tishreen University Journal for Research and Scientific Studies - Health Sciences Series
Under a CC BY- NC-SA 04 license that allows others to share the work with of the work's authorship and initial publication in this journal. Authors can use a copy of their articles in their scientific activity, and on their scientific websites, provided that the place of publication is indicted in Tishreen University Journal for Research and Scientific Studies - Health Sciences Series . The Readers have the right to send, print and subscribe to the initial version of the article, and the title of Tishreen University Journal for Research and Scientific Studies - Health Sciences Series Publisher
journal uses a CC BY-NC-SA license which mean
You are free to:
- Share — copy and redistribute the material in any medium or format
- Adapt — remix, transform, and build upon the material
- The licensor cannot revoke these freedoms as long as you follow the license terms.
- Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- NonCommercial — You may not use the material for commercial purposes.
- ShareAlike — If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
