Effect of Non-Surgical Periodontal Therapy on Serum Cystatin C Levels in Patients with Periodontitis with and without Chronic Kidney Disease

Abstract

Introduction: Periodontitis is an inflammatory disease associated with systemic conditions, including chronic kidney disease (Cystatin C is a biomarker reflecting both renal function and systemic inflammatory status. This study aimed to evaluate the effect of non-surgical therapy on serum cystatin C levels in periodontitis patients with and without chronic kidney disease (CKD).

Materials and Methods: The study included thirty patients divided into three groups: a control group, a group with periodontitis only (systemically healthy), and a group with periodontitis and CKD. Serum samples were collected before and four weeks after non-surgical therapy. Cystatin C levels were measured using nephelometry.

Results: The results showed no statistically significant decrease in serum cystatin C levels, particularly in patients with CKD.

Conclusion: Although non-surgical therapy was effective in improving periodontal health, it did not significantly affect serum cystatin C levels in renal patients. This may indicate cystatin C's nature as a biomarker that primarily reflects stable renal function and systemic