Study the possibility of using the extract of the Ammi visnaga. L Fruits in green pharmaceutical cosmetic formulations

Abstract

Ammi visnaga L., commonly known as toothpickweed, represents a natural resource rich in bioactive compounds and has been traditionally used in folk medicine to treat a variety of diseases and skin conditions. Given the therapeutic potential of Ammi visnaga L., we evaluated the possibility of using it in the development of innovative and safe green pharmaceutical preparations. Ultrasonic-assisted extraction technology was used as an effective and economical method to extract the active compounds from the fruits of Ammi visnaga L. using distilled water as a solvent. Chemical composition analysis of the resulting extract using Gas Chromatography-Mass Spectrometry (GC-MS) revealed the presence of a range of biologically active compounds, most notably: methyl isoeugenol (64.4%), known for its antifungal properties; mandelic acid ester (13.3%), characterized by its exfoliating and skin-lightening properties; and khellin (3.59%), which possesses soothing properties. Based on these results, two topical cream formulations were developed, one with a preservative and the other without, to evaluate the effect of preservatives on product stability. A model of an aqueous serum from the fruit extract for skincare was also developed. A series of tests were conducted to evaluate the safety and stability of the formulations, including skin tests that showed no sensitivity or irritation, as well as physical and biological tests to assess pH, color, odor, and microbial growth.