Encapsulation of curcumin and diclofenac mixture with sodium alginate and chitosan and evaluation of the encapsulation efficiency
Abstract
Curcumin synergizes with diclofenac to achieve a dose-related anti-inflammatory effect. Curcumin has an activity similar to that of diclofenac, allowing for reduction in side effects. Curcumin inhibits enzymes in the digestive system that destroy diclofenac, which increases the bioavailability of diclofenac, micro capsules of a mixture of curcumin and diclofenac were prepared using polymeric coatings such as sodium alginate with different concentrations and chitosan with specific concentrations in combination with sodium alginate of constant concentration after adding it to a calcium chloride solution.
The encapsulation efficiency when using sodium with a concentration of (3.5%), and calcium chloride with concentration of (2.5%), was 89.5% for curcumin and 98.3% for diclofenac. As for chitosan with sodium alginate at concentrations (0.5 to 3.5) %, the encapsulation rate for curcumin was 85.9% and for diclofenac was 87.5%, as the research results confirm that It is possible to adopt this method in encapsulation of a mixture of curcumin and diclofenac because it is fast, accurate, and has very good encapsulation efficiency.
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